陶歌课题组位于南卡医科大学，再生医学与细胞生物学系 （https://medicine.musc.edu/departments/regenerative-medicine/research/tao-lab ）。现招聘博士后研究员 （两名）。本课题组主要利用原代细胞，干细胞和动物模型筛选能够促进受损心肌修复的再生因子。实验项目侧重生理，细胞生物学，分子生化以及信号转导。日常使用技术包括各类测序和多种小鼠心肌损伤模型。过去论文发表请见（https://www.ncbi.nlm.nih.gov/myncbi/1VUH-Uoecmpkm/bibliography/public/ ）。
申请人要求：
• 博士学位：生物学，生命科学或医学背景；
• 基本英文写作，交流能力；
• 擅长团队合作；
• 生物信息，心脏病，模式动物心血管生物学研究背景者优先。
待遇：
• 美国国立卫生研究院博后标准年薪，以及南卡医科大学标准博后福利
有意者请将简历发送至Dr. Ge Tao邮箱：t[email protected]
Cardiac development and regeneration laboratory postdoc scholar recruitment, Medical University of South Carolina
The Tao lab is dedicated to unveiling the cellular and molecular mechanisms underlying myocardial homeostasis, injury, and repair. We are interested in understanding how developmental pathways are connected to adult heart regeneration after myocardial infarction (MI). MI often leads to degenerative muscle that gradually loses healthy cardiomyocytes and contractility. Currently, there is no cure to reverse the pathological progress. To repopulate the infarcted myocardium, one promising strategy is to reintroduce the terminally differentiated cardiomyocytes into cell cycle. In mouse, neonatal hearts can fully regenerate after MI, however this ability is gradually lost and gone by Postnatal day 7. Over the past 7 years, we and other groups have been trying to figure out what the young hearts have, and the adult hearts don’t. It turned out that certain molecular pathways are enriched in neonatal hearts and grant them regenerative abilities. The same pathways, when genetically modified, can improve cardiac repair in adult hearts. One such example is the Pitx2 signaling. In injured neonatal mouse heart, the Pitx2 gene is activated by the upstream redox sensor Nrf2. Nrf2 then facilitates the nuclei-shuttling of Pitx2 protein, which further couples with the Hippo signaling effector, Yap, to co-regulate downstream antioxidant scavengers (Tao et al., Nature 2016).
The projects in our lab typically start with unbiased screening using CRISPR technology and NGS. Once a target pathway has been identified, it will be validated in cell lines and tissue samples. Eventually, each hypothesis will be examined using an adult murine heart survival surgery model, where artificial MI is induced by occluding the left anterior descending coronary artery. The effect of gene manipulation on the scarring and recovering of the myocardium will be assessed by non-invasive echocardiography, histology, immunofluorescence, and biochemistry. Trainees in the Tao lab will have the opportunities to learn the key technologies and skills mentioned above. We welcome enthusiastic postdocs to join our lab.
Eligibility:
• Candidates holding a PhD, MD or MD/PhD degree with training background in biology, life science or medical science;
• Basic communicating and writing skills; good with teamwork and collaboration;
• Bioinformatic, cardiovascular biology training experience is highly recommended.
Salary:
NIH standard postdoc salary plus fringe benefits from the Medical University of South Carolina.
Applicants interested in a postdoc position please send the CV to the PI, Dr. Tao, at[email protected]
Full contact:
Ge Tao, PhD
Assistant Professor,
Dept. Regenerative Medicine & Cell Biology, MUSC
173 Ashley Ave, BSB-642 / MSC 508
Charleston, SC 29425
Email: [email protected]
Office: 843-792-5059
